Revista Brasileira de Psiquiatria ISSN print 1516-4446
ISSN on-line 1809-452X
JCR IF 2017: 2.093
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Braz J Psychiatry Ahead of Print

The validity and reliability of the CAMDEX-DS for assessing dementia in adults with Down syndrome in Brazil

Luciana M. Fonseca1,2; Glenda G. Haddad1; Guilherme P. Mattar1; Melaine C. de Oliveira3; Sharon S. Simon1; Laura M. Guilhoto4,5; Geraldo F. Busatto1,6; Shahid Zaman2; Anthony J. Holland2; Marcelo Q. Hoexter7; Cassio M. Bottino1

1. Programa Terceira Idade (PROTER), Departamento e Instituto de Psiquiatria, Hospital das Clnicas, Faculdade de Medicina, Universidade de So Paulo (USP), SP, Brazil
2. Cambridge Intellectual and Developmental Disabilities Research Group, Department of Psychiatry, University of Cambridge, Cambridge, UK
3. Department of Statistics, Florida State University, Tallahassee, FL, USA
4. Associao de Pais e Amigos dos Excepcionais de So Paulo (APAESP), So Paulo, SP, Brazil
5. Departamento de Neurologia e Neurocirurgia, Universidade Federal de So Paulo (UNIFESP), So Paulo, SP, Brazil
6. Laboratrio de Neuroimagem em Psiquiatria (LIM 21), Departamento e Instituto de Psiquiatria, Hospital das Clnicas, Faculdade de Medicina, USP, So Paulo, SP, Brazil
7. Projeto Transtornos do Espectro Obsessivo-Compulsivo (PROTOC), Departamento e Instituto de Psiquiatria, Hospital das Clnicas, Faculdade de Medicina, USP, So Paulo, SP, Brazil

Luciana Mascarenhas Fonseca
Programa Terceira Idade, Instituto de Psiquiatria, Hospital das Clnicas, Faculdade de Medicina, Universidade de So Paulo
Rua Dr. Ovidio de Campos, 785, Cerqueira Cesar
CEP 05403-010, So Paulo, SP, Brazil

Submitted Jan 24 2018
Accepted May 07 2018

Descriptors: Alzheimer disease; Down syndrome; diagnosis; dementia; intellectual disability
OBJECTIVE: Alzheimer's disease occurs at a higher prevalence and an earlier age in individuals with Down syndrome (DS) than typically developing individuals. However, diagnosing dementia in individuals with intellectual disability remains a challenge due to pre-existing cognitive deficits. The aim of this study was to investigate the validity and reliability of the Brazilian version of the Cambridge Examination for Mental Disorders of Older People with Down's syndrome and Others with Intellectual Disabilities (CAMDEX-DS) for individuals with DS.
METHODS: Two psychiatrists, working independently, evaluated 92 adults with DS ≥ 30 years of age. The concurrent validity of the CAMDEX-Ds was analyzed in relation to the gold standard of established international criteria. In a subgroup of 20 subjects, the concurrent validity of the CAMDEX-DS was analyzed in relation to an independent objective assessment of cognitive decline over three years. We analyzed the inter-rater reliability of cognitive assessment.
RESULTS: The diagnostic accuracy of the CAMDEX-DS compared to the gold standard was 96.7%. CAMDEX-DS-based diagnosis was considered consistent with cognitive decline. The probability of a participant with dementia having cognitive decline was 83%. Inter-rater reliability for the participant assessment was good, with a kappa of > 0.8 for 93% of the CAMDEX-DS items.
CONCLUSION: The CAMDEX-DS can be considered the first valid and reliable instrument for evaluating dementia in adults with DS in Brazil. Its use in such individuals could improve clinical practice and research.


Down syndrome (DS) is a chromosomal anomaly caused by the presence of an extra copy of chromosome 21.1 There are no official estimates of the prevalence and incidence of DS in Brazil. However, in a collaborative study involving 129 maternity hospitals in nine South American countries (including Brazil), the live birth prevalence rate of DS between 1995 and 2012 was reported as 0.12%.2 The estimated live birth prevalence of DS in the United States was approximately 0.14% between 2004 and 2006.3 In England, the live birth prevalence of DS in 2010 was approximately 0.10%, 54% less than expected due to screening programs and consequent abortions.4 The characteristics of DS can include the physical phenotype (hypotonia, short stature, protruding tongue, and flattened facial appearance) and the clinical presentation of neuropsychological developmental delay that results in intellectual disability in most individuals with DS.

There is a genetic link between DS and the early development of neuropathological features of Alzheimer's disease (AD) during adult life.5 That association is explained in part by the extra copy of chromosome 21, a chromosome linked to the overexpression of certain proteins related to the neurodegeneration process, including the protein precursor of β-amyloid in the brain and superoxide dismutase 1.6 Thus, the triplicate copy of chromosome 21 leads to higher levels of proteins related to AD in DS brains. In addition, DS is associated with premature structural brain aging.7 Post-mortem studies have shown that virtually all individuals with DS show neuropathological signs of AD after reaching 40 years of age, including senile plaques containing β-amyloid and neurofibrillary tangles.5 Because of the pathological similarity of AD among individuals with DS, research in this population has great potential to advance understanding of AD in the general population. Neuroimaging studies have demonstrated β-amyloid deposition in individuals ≥ 40 years of age with DS, appearing first in the striatum, followed by prefrontal-cingulo-parietal areas,8 and occurring prior to the onset of dementia.9 However, the psychiatric and neuropsychological features of the symptomatology of AD in DS can be considerably different than those expected for the general population.10

The specificities of the progression of AD in individuals with DS, together with the presence of previous cognitive deficits attributed to intellectual disability, make the diagnosis of dementia in this population challenging. It requires diagnostic assessment procedures that incorrate the specific information necessary to enable an accurate clinical diagnosis. Instruments used to detect cognitive decline in the general population are not suitable for individuals with DS, because they are based on studies of individuals with typical intellectual development and have not been adapted for use in individuals with a low basal level of cognitive and functional abilities. Although several instruments have been developed or adapted for this population in Europe and the United States,11-14 none have been translated to Portuguese or validated for use in Brazil. Consequently, there are no instruments available for diagnosing dementia in individuals with DS in Brazil. The Cambridge Examination for Mental Disorders of Older People with Down's syndrome and Others with Intellectual Disabilities (CAMDEX-DS)11 is a diagnostic instrument consisting of an objective neuropsychological assessment of the individual with DS (CAMcOg-DS) and a detailed interview to be conducted with an informant, which allows a decline from the individual's best level of functioning to be established.15 The CAMDEX-DS is designed to provide support for good clinical and research practices. In a review including an analysis of instruments used in recent years,10 the CAMDEX-DS was the only diagnostic assessment tool that was based on standardized international criteria, was designed for use in individuals with intellectual disability and AD, is administered to an informant, and includes a direct cognitive assessment of the subject. The CAMDEX-DS was found to be one of the most widely used instruments in studies in this area. In this paper, we report on the validity and reliability of the CAMDEX-DS for diagnosing dementia in a population of individuals with DS in Brazil.



The study was approved by the research ethics committee of the Hospital das Clnicas, Universidade de So Paulo (USP), and was registered with the national committee for ethics in research through Plataforma Brasil (CAAE no. 37381414.8.0000.0065).

Study design

This was a cross-sectional, case-control study with longitudinal analysis for a subgroup of participants.


The study was carried out by the Programa Terceira Idade (pRotER) of the Instituto de Psiquiatria, Hospital das Clnicas, Faculdade de Medicina, USP, in partnership with the Associao de Pais e Amigos dos Excepcionais de So Paulo (APAESP) and the Associao para o Desenvolvimento Integral do Down (ADID). Assessments were performed at the hospital or at one of the involved associations, depending on the logistics (i.e., the most convenient location for the participants and their families). In some cases, when a participant's or informant's mobility was limited, parts of the evaluations were performed in their home. In all cases, the assessments were carried out in silent rooms arranged for the evaluation. When the assessments were divided over testing sessions, the time between them was 1 or 2 weeks at most.


All participants met the ICD-10 criteria for a diagnosis of DS (code, Q90) and were ≥ 30 years of age. The majority of the participants were or had previously been enrolled in APAESP or ADID. Eight additional individuals were included in the study after meeting participants. APAESP and ADID identified eligible participants and provided a list of contacts. The objectives of the study were explained to all participants in a simple, concrete manner, and any questions or concerns had were addressed. Due to their intellectual disability, written informed consent was obtained not only from the participants, but their legal guardians as well. Figure 1 illustrates the process of selecting subjects for inclusion in the study.

Figure 1 Flow chart of the participant inclusion process. ADID = Associao para o Desenvolvimento Integral do Down; APAESP = Associao de Pais e Amigos dos Excepcionais de So Paulo; DS = Down syndrome.


The CAMDEX-DS11 is a version of the CAMDEX scale,16 modified and adapted for DS, that incorporates the specific information necessary to enable an accurate clinical diagnosis and to facilitate the differential diagnosis of any observed decline in this population. It takes into account pre-morbid difficulties, establishing decline from the individual's best level of functioning. The CAMDEX-DS includes informant and participant interviews with objective assessment of cognitive function, as well as a standardized schedule for recording observations, physical examination findings, and laboratory test results. The domains covered in the CAMDEX-DS informant interview are: Participant's Best Level of Functioning (education and employment, basic skills, and independent living); Cognitive and Functional Decline (everyday skills, memory, orientation, general mental functioning, language, perception, praxis, executive functions, personality, behavior, and self-care); Current Mental Health (depression, anxiety, paranoid illness, clouding/delirium, and substance abuse); and Current Physical Health (physical disability, hypothyroidism, cerebrovascular problems, other physical illness, and medication).

Bottino et al. translated the CAMDEX to Portuguese and culturally adapted and validated it for use in Brazilian adults from the typically developing population with dementia.17 The reliability of the syndromic diagnosis of dementia, as determined by calculating the kappa statistic (κ), was excellent (κ = 0.94) and that of the etiological diagnosis was good (κ = 0.83), both with a p-value of 0.001. In Brazil, the Portuguese-language version of the CAMDEX has shown good applicability and is widely used by clinicians and researchers.18-20

The original CAMDEX-DS validation study involved 74 individuals ≥ 30 years of age with DS in England.11 For diagnosing AD, the CAMDEX-DS showed a specificity of 0.94 and a sensitivity of 0.88. The inter-rater reliability was considered good (κ > 0.8) for 91% of the items and fair (κ > 0.6) for all of the items collectively. The CAMDEX-DS has also been validated for use in Spain.21 It is now widely used in studies of individuals with DS and intellectual disability.7,8,22,23


The Cambridge Cognitive Examination adapted for individuals with Down Syndrome (CAMCOG-DS) is a concise group of neuropsychological tests included in the CAMDEX-DS. It was designed to ensure that most individuals with DS score above the test floor, thus improving the detection of cognitive decline. Some questions from the original CAMCOG were removed after proving to have a high floor effect; in other CAMCOG-DS questions, the participant can acquire a half-score because the interviewer is allowed to provide clues as needed. The CAMCOG-DS comprises subscales for the following domains: orientation; language (comprehension and expression); memory (new learning, remote, and recent); attention; praxis (drawing complex figures and the ability to carry out complex tasks); abstract thinking; and perception. The maximum total score on the CAMCOG-DS is 109 points.

Hon et al.24 showed that the CAMCOG can differentiate between older and younger individuals with DS. The authors concluded that, with minor modifications, the CAMCOG is a useful test for evaluating areas of cognitive function that are known to deteriorate in dementia. In addition, the decline in CAMCOG scores was greater in participants who had been diagnosed with dementia than in those who had not.

The CAMCOG-DS is a reference for studies investigating cognitive processes in adults with intellectual disability.23,25-27 In one study of individuals with DS in Brazil, a longitudinal comparison of individual performance on the CAMCOG was found to enrich the analysis of cognitive decline.28

Translation and cultural adaptation of the CAMDEX-DS for use in Brazil29

The content validation of the CAMDEX-DS involved the following steps: initial translation to Portuguese; cultural adaptation with assistance of a multidisciplinary team assembled from the PROTER Research Group; evaluation of the cognitive portion of the translated, adapted version for equivalence (semantic, idiomatic, conceptual, and experimental) and comprehension by two neuropsychologists, working independently; suggestions made by the two neuropsychologists; re-adaptation taking those suggestions into account; re-evaluation of the new version; back-translation into the original English by a free-lance bilingual translator with no access to the original version; evaluation (by the original authors) of the equivalence of the modified cognitive portion; and a pilot test involving 10 adults with DS who did not participate in the subsequent validation study. The pilot was considered comprehensive, requiring no further modifications.

Diagnostic categories

We established three diagnostic categories: AD, prodromal dementia, and stable cognition. Prodromal dementia was defined as evidence of cognitive decline that was more severe than that expected for the stable cognition group, but not severe enough to meet the criteria for AD. The categories were established separately based on the CAMDEX-DS guidelines and the gold standard.

Diagnostic assessment using the CAMDEX-DS

The CAMDEX-DS questionnaire was administered by a trained psychiatrist who made the diagnosis based on the CAMDEX-DS guidelines and the CAMCOG-DS results, but was blinded to all other assessments and information. CAMDEX inclusion criteria for AD indicate a decline in: a) everyday skills; b) memory; and c) one of the following: general mental functioning, language, praxis, object recognition, executive function, and/or personality and behavior. The duration of the changes must be greater than six months with gradual onset and no evidence of clouding/delirium, signs of vascular dementia, or secondary dementia. The time required to administer the CAMDEX-DS questionnaire to the informant varied from 40 to 60 minutes.

Gold standard diagnostic procedure

A psychiatrist trained in geriatrics and intellectual disability performed the gold standard diagnostic evaluation. Because of the challenge of using a gold standard for diagnosing dementia in individuals with DS in Brazil, the evaluation was based on criteria established in the Diagnostic Manual - Intellectual Disability,30 the DSM-531 and the ICD-10,32 with the rater blinded to the CAMDEX-DS-based diagnosis. In addition to a structured clinical interview, the rating psychiatrist applied the Informant Questionnaire on Cognitive Decline in the Elderly,33 the Neuropsychiatric Inventory,34 and the Frontal System Behavior Scale.35 The rater also had access to neuropsychological assessment data other than the CAMCOG score, as well as to all available medical records. The time required for the gold standard diagnosis varied from 90 minutes to 120 minutes.

Neuropsychological assessment

A neuropsychologist applied the CAMCOG-DS and the Wechsler Abbreviated Scale of Intelligence.36 The total time required to apply the instruments varied from 90 minutes to 120 minutes. When necessary, the evaluation was divided into two sessions with a maximum of 1 week between them.

Concurrent validity between the CAMDEX-DS and the gold standard

The concurrent validity between the CAMDEX-DS and the gold standard clinical diagnostic procedure was established through the agreement level of diagnoses made by each method.

Concurrent validity between the CAMDEX-DS and objective assessment of cognitive decline over 3 years

We examined the concurrent validity between the CAMDEX-DS and an objective assessment of cognitive decline for 20 subjects in our sample who had participated in a previous longitudinal study by our team involving the CAMCOG.28 The second CAMCOG assessment was performed when the CAMDEX-DS was applied. Cognitive decline was defined as one standard deviation (SD) below the mean change in CAMCOG score.11

Inter-rater reliability of the CAMCOG-DS

For the inter-rater reliability analysis of the CAMCOG-DS, the responses of 20 individuals with DS were rated simultaneously and independently by the neuropsychologist who conducted the cognitive assessment and a psychiatrist who observed the assessment. The results of the items and subscales were compared for each participant.

Statistical analysis

To determine the concurrent validity between the gold standard diagnosis and the CAMDEX-DS-based diagnosis, we calculated type I errors, type II errors, sensitivity, specificity, accuracy, predictive value, and the likelihood ratio. We also analyzed the agreement between the two variables by calculating the kappa statistic. To determine inter-rater reliability, the level of agreement between the interviewers was also analyzed by calculating the kappa statistic. To analyze the concurrent validity between the CAMDEX-DS-based diagnosis and the cognitive decline assessment, we compared the groups' 95% confidence intervals (95%CI) for cognitive decline, crosstabulated the data, performed Fisher's exact test, and calculated the odds ratio (OR). For the sample as a whole, assumptions of homogeneity of demographic features among groups (stable cognition vs. prodromal dementia vs. AD) were verified with the Kruskal-Wallis test (for continuous variables) or Fisher's exact test (for categorical variables). The level of statistical significance was set at p < 0.05. All selected data were tabulated with the Research Electronic Data Capture (REDCap) program37 and analyzed with SPSS version 14.


Demographic data

Table 1 shows the demographic characteristics of the sample as a whole, as well as comparisons among the groups. The overall prevalence of AD was 11.9%, whereas that of prodromal dementia was 19.6% (based on the gold standard).

All informants had known the participant for at least 10 years, and the majority were family members or primary caregivers. We found that there were considerably more primary caregivers who were not the parents in the prodromal dementia and AD groups than in the stable cognition group.

Concurrent validity between the CAMDEX-DS and the gold standard

The analysis of concurrent validity between CAMDEX-DS and the gold standard included 92 individuals. Compared to the gold standard, the CAMDEX-DS had a specificity for dementia (proportion of individuals accurately identified as having no dementia) of 98.4% and a sensitivity for AD (proportion of individuals accurately identified as having Ad) of 100%. In addition, the CAmDeX-DS had a sensitivity of 88.9% for diagnosing prodromal dementia.

Therefore, the overall accuracy of the CAMDEX-DS was 96.7%, i.e., the proportion of true positives and true negatives among all evaluated cases (Table 2). The predictive value or precision (ratio of true positives to combined true and false positives) of the CAMDEX-DS-based AD diagnosis in this sample of individuals ≥ 30 years of age with DS was 84.6%, whereas it was 94.1% for the CAMDEX-DS-based prodromal dementia diagnosis. The kappa statistic for the agreement between the CAMDEX-DS and the gold standard was 0.93 (p < 0.05).

Concurrent validity between CAMDEX-DS and cognitive decline over three years

The CAMDEX-DS-based diagnosis was cross-tabulated with a decline in CAMCOG scores over a 3-year period in a subgroup of 20 participants. At baseline, none of them was diagnosed with dementia. Of those 20 participants, 12 (60%) were male. The mean age of the participants was 47.8 years (SD 6.81), ranging from 39 to 60 years. Those whose CAMCOG score declined > 5.8 points - at least 1 SD (9.38) from the mean change for the group (-3.5) - were significantly more likely to be diagnosed with AD or prodromal dementia (p = 0.049, Fisher's exact test). Of the 11 participants in the stable cognition group, only one (9.1%) showed such a decline. Among the six participants diagnosed with prodromal dementia, the CAMCOG score declined by > 5.8 points in two (33.3%), by < 5.8 points in two (33.3%), and improved overall by 3 points in two (33.3%). The CAMCOG score of all three

individuals diagnosed with AD declined by > 5.8 points. The 95%CI for cognitive decline did not intersect between the stable cognition and AD groups (95%CI -2.25 to 4.07 vs. -39.39 to -4.61), which indicates that there is a distinction between them. This was not the case for the prodromal dementia group (95%CI -7.15 to 2.48), indicating that it is an intermediate group between the stable cognition and AD groups. For the AD and prodromal groups together, the 95%CI for cognitive decline over the three years ranged from -17.38 to -0.39. The probability of a > 5.8 point decline in CAMCOG score was 83% for those diagnosed with AD or prodromal dementia (OR = 12.5, 95%CI 1.08 to 143.43).

Inter-rater reliability of the CAMCOG-DS

For the inter-rater reliability analysis, we collected data on a subgroup of 20 participants, eight (40%) of whom were male. The mean age was 44.80 years (SD 7.51 years; range, 32-60 years). One (5%) was diagnosed with AD and six (30%) with prodromal dementia. Ten (50%) had mild intellectual disability, nine (45%) had moderate intellectual disability, and one (5%) was classified as having unspecified intellectual disability due to cognitive decline without a prior classification. Although the interrater agreement was excellent (κ > 0.90, p < 0.001) for most (87%) of the CAMCOG-DS items, it was lower (κ = 0.80-0.90, p < 0.001) for three items (6%). Table 3 presents items for which the kappa statistic was < 0.8.


Diagnosing dementia in individuals with a history of cognitive impairment, such as people with DS, continues to be a challenge due to the lowered baseline functioning and pre-existing abnormalities in brain development. In this study, we have demonstrated that the Portuguese-language version of the CAMDEX-DS, adapted for use in Brazil, is highly accurate for diagnosing dementia and identifying cognitive and functional prodromal decline in individuals with DS. The CAMDEX-DS could detect nearly all of the cases of prodromal dementia and AD that were diagnosed with the gold standard method, providing a faster and standardized interview. Of the participants testing positive for AD on the CAMDEX-DS, 84% were considered true positive, as were 94% of those testing positive for prodromal dementia. The ability of the CAMDEX-DS to refute other diagnoses was also good. The level of agreement between the CAMDEX-DS-based and gold standard diagnoses was similar to that found in the validation study conducted in Spain.21 The majority of the CAMCOG-dS items presented excellent inter-rater reliability (κ > 0.8).

We found that age had a strong influence on the selected variables, which can be explained by the known associations among age, cognitive decline, and AD.38 The stable cognition group was considerably younger than the prodromal dementia group, just as the prodromal dementia group was younger than the AD group. Prodromal dementia appeared as a transitional stage in this population, as is the case for mild cognitive impairment in the general population.39 The key difference is that the age of onset for cognitive decline and dementia in this population is nearly 20 years earlier than that reported for the general population, which corroborates the findings of previous studies showing that individuals with DS present early aging.40

Despite the excellent validity and reliability observed for the CAMDEX-DS, the importance of training in its application and interpretation should be stressed. Although the CAMDEX-DS guides the investigation to elucidate aspects necessary for an adequate evaluation, a CAMDEX-DS-based diagnosis still relies on clinical judgement. Just as with the use of the CAMDEX in the general population, there is no formula or cutoff score that directly indicates a specific diagnosis; knowledge in the area and a clinical appraisal are of fundamental importance. Nevertheless, at the end of the questionnaires, the CAMDEX provides a guide for clinical diagnosis, with information on universally accepted diagnostic criteria and guidelines for classifying the severity of dementia, thus offering support for this process. It is also of note that a CAMDEX evaluation places great emphasis on the information provided by the informant, thus requiring this person to have known the individual for quite some time, preferably having seen him/her quite frequently. Our finding that the number of primary caregivers who were not the parents tended to increase in parallel with an increase in the degree of dementia is probably attributable to the comparable relationship between the age of the participants and their cognitive decline: as individuals with DS age, their parents are more likely to die or become unable to provide care. This underscores the need to adapt care and public policies targeting this population in developing countries such as Brazil.

Our study has some limitations that should be considered. First and foremost is the lack of a validated instrument for diagnosing AD in individuals with DS in Brazil to use as a gold standard. However, to our knowledge, this is the first study attempting to determine the validity and reliability of a specific instrument for AD in individuals with DS in Brazil. We attempted to reduce this gap by using internationally recognized criteria adapted for this population,30 as well as by determining its validity as measured against the cognitive decline observed in a subsample. We attempted to conduct an accurate investigation of all areas known to deteriorate in adults with DS and included instruments that have previously shown good applicability.28 Another limitation of our study is that both psychiatrist raters received the same training regarding intellectual disability and aspects related to aging in DS. Although we consider this training essential for both assessments, it could have been at least partially responsible for the high agreement rates. We believe that both raters had the knowledge necessary to make an accurate clinical evaluation, despite using different instruments for data collection and different diagnostic guidelines. Another limitation is that sedentary lifestyle, intellectual disability, the use of medication affecting the central nervous system, and a family history of AD all showed significant differences among groups. Our cross-sectional study design prevented us from distinguishing the nature of those associations. For example, it is possible that the participants with prodromal dementia or AD became sedentary due to a functional decline. The degree of intellectual disability could be related to the level of cognitive reserve, as well as our inability to determine whether such deficits were associated with psychiatric symptoms. The use of medication that affects the central nervous system might be due to treatment for neuropsychiatric symptoms related to AD. Data in the literature suggest that a family history of AD is a risk factor for developing the disease in the general population.41 However, in our sample, the appearance of cognitive decline symptoms might have focused more attention on family history. Furthermore, as with any other cognitive test applied in this population, the CAMCOG-DS has limited diagnostic value in a single evaluation. Without baseline measurements, it is impossible to determine to what extent cognitive malfunction is a consequence of a previous deficit or of another disorder that may affect cognitive ability, which thus might not necessarily be a decline. Nevertheless, a cognitive decline over time provides a useful complement to the diagnostic and support process, as evidenced in our longitudinal comparison, despite the small sample size. In addition, although most CAMCOG-DS items presented excellent inter-rater agreement, three items in particular were more difficult to score, perhaps because they presented more abstract concepts. A more detailed definition of the scores may help improve the evaluation of these items. The small number of participants in our longitudinal analysis of objective cognitive decline is another limitation of our study. Further studies are needed to explore these questions.

To our knowledge, this is the first study to validate an instrument for detecting AD and cognitive decline in individuals with DS in Brazil. Given the challenges of early detection of neurodegenerative diseases in individuals with DS, there is a need for an assessment instrument that contemplates the specificities of the aging process in this population. The CAMDEX-DS appears to be a valid and reliable instrument for facilitating the early identification of cognitive and functional changes, as well as for refining the diagnosis of individuals with DS in Brazil, thus allowing care to be adapted to their demands and supporting further research in this area.


We dedicate this article to Prof. Cassio Machado de Campos Bottino (in memoriam), who closely supervised the study from beginning to end. We would like to thank all the participants and their families; APAESP and ADID; and the PROTER Research Group. We are also grateful to Juliana Emy Yokomizo and Sharon Sanz Simon, for analysis of comprehension and equivalence; Juliana Mascarenhas Fonseca, for back-translation; Prof. Rita Ferreira de Cassia Alves, for her suggestions about the adaptation; and Debora Boschetti, for her help with the pilot study. This study was supported by the Fundao de Amparo Pesquisa do Estado de So Paulo (FAPESP; grants 2013/11571-9 and 2016/22123-5).


The authors report no conflicts of interest.


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