Revista Brasileira de Psiquiatria ISSN print 1516-4446
ISSN on-line 1809-452X
JCR IF 2017: 2.093
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Aggression directed towards others vs. aggression directed towards the self: clinical differences between intermittent explosive disorder and nonsuicidal self-injury

Gustavo C. Medeiros1; Liliana Seger-Jacob2; Anna K. Garreto2; Hyoun S. Kim3; Emil F. Coccaro4; Hermano Tavares2

1. Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA;
2. Departamento de Psiquiatria, Instituto de Psiquiatria, Hospital das Clnicas, Faculdade de Medicina, Universidade de So Paulo, So Paulo, SP, Brazil
3. Department of Psychology, University of Calgary, Calgary, AB, Canada
4. Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA

Gustavo Costa Medeiros
Department of Psychiatry, University of Texas Southwestern Medical Center
5323 Harry Hines Blvd
75390-9070, Dallas, TX, USA

Submitted May 07 2018
Accepted Aug 11 2018

Descriptors: Aggression; intermittent explosive disorder; nonsuicidal self-injury
OBJECTIVE: To investigate the clinical differences between intermittent explosive disorder (IED) (disorder of aggression primarily directed towards others) and nonsuicidal self-injury (NSSI) (disorder of aggression predominantly directed towards the self) in order to better understand the different clinical subtypes of aggression.
METHODS: We used treatment-seeking samples to compare demographic and clinical correlates between 82 participants with IED and 55 participants with NSSI.
RESULTS: The IED group was older, more likely to be male, in a relationship, and employed than the NSSI group. With respect to clinical variables, the NSSI group had more severe depressive symptoms and more social adjustment difficulties. Regarding psychiatric co-morbidities, the IED group had higher rates of generalized anxiety disorder. On the other hand, the NSSI group had higher rates of major depressive disorder, agoraphobia, substance use disorder, and bulimia nervosa.
CONCLUSIONS: Individuals with NSSI may benefit from better management of psychiatric comorbidities, specifically depressive symptoms and social adjustment difficulties. Conversely, the treatment of individuals with IED may be improved by targeting comorbid generalized anxiety disorder. Our results provide important insight for the development of tailored interventions for specific subtypes of aggression.


Pathological aggression is associated with substantial physical, psychological, and economical burden.1-4 Despite its negative impacts on society and its potential to cause intrapersonal and interpersonal harm, aggression has only recently been empirically investigated in the field of psychiatry and clinical psychology. Nevertheless, mental health intervention may benefit a number of mental disorders linked to aggression.4 Unfortunately, due to gaps in the empirical literature, individuals with aggressive behavior are not being effectively treated. Specifically, there is a lack of understanding on the different subtypes of aggression, and resolving this lack of understanding may help develop tailored interventions.

The present study classified aggression based on the target of the aggressive behavior: aggression directed towards others vs. aggression directed towards the self.2 Intermittent explosive disorder (IED) is considered a hallmark diagnosis of aggression directed towards others3,5 with 89% of individuals showing aggression against other people and the remaining 11% against property.6 The lifetime prevalence of IED has been estimated to be 6.9% in the United States and 3% in studies outside of the United States.3 To the best of our knowIEDge, no national studies have been conducted in Brazil. However, studies have estimated the lifetime prevalence in the city of So Paulo, Brazil, at 4.9%.7 The high rate of IED in the general population suggests that aggression directed towards others may be an important public health issue and warrants greater empirical investigation.3,6,8 Another way that people manifest aggression is self-injurious behavior.2 One of the most common means of aggression directed towards the self is nonsuicidal self-injury (NSSI).9 In NSSI individuals do not intend to commit suicide, but to cause physical harm to themselves.9,10 Self-injurious behavior is often an attempt to obtain relief from negative feelings or thoughts.9,10 nSsi is a common and significant problem.9-11 A systematic review of data from Asia, North America, Oceania, and Europe estimated the lifetime prevalence of NSSI between 5.5 and 17.2%.12 Although suicide is not the goal of NSSI, previous evidence has suggested that NSSI is a predictor of future suicide attempts and completed suicide.11 Frequent forms of selfinjury include cutting, scratching, burning, hitting, and scraping.9,10 Thus, NSSI may be a good representation of the subtype of aggression directed towards the self.

In the present study, we propose that comparing clinical correlates between IED (aggression disorder primarily directed towards others) and NSSI (disorder of aggression predominantly directed towards the self) may provide a better understanding of the different subtypes of aggression. In support of this supposition, the available evidence suggests that IED and NSSI have different demographic and clinical profiles. IED appears to predominantly affect males6 while NSSI tends to be more prevalent in women.10 Individuals with IED tend to have higher rates of other externalizing and impulse-control disorders,6 whereas individuals with NSSI appear to have elevated rates of mood disorders.12 While the limited empirical literature provides preliminary evidence of the potential differences between IED and NSSI, no direct investigation of the similarities and differences between IED and NSSI has been conducted. This is a gap in the literature since previous clinical trials have suggested that tailored treatments for specific subtypes of aggressive behaviors may increase treatment efficacy.13,14 For example, IED-focused cognitive-behavioral psychotherapy that specifically targets cognitive distortions and automatic thoughts related to IED, such as interpreting neutral stimuli as threats, as well as assertiveness training, appears to improve outcomes. Unfortunately, tailored treatments for IED are scarce.13,14 Furthermore, tailored interventions targeting self-aggression (i.e., NSSI) are rare15,16 and are usually based on treatments for other disorders, including dialectic behavioral therapy, which was developed to treat borderline personality disorder.15

In light of these issues, the objective of the present study was to directly investigate the clinical differences between individuals whose aggression is predominantly directed towards others (IED) and individuals whose aggression is primarily directed towards the self (NSSI). To this end, we compared demographics and clinical variables between the two groups. The results of the present study may provide further insight into the differences between IED and NSSI and may aid in the development of tailored interventions based on subtypes of aggression.



The sample consisted of 137 consecutive treatment-seeking patients from the Programa Ambulatorial Integrado dos Transtornos do Impulso (PRO-AMITI), Instituto de Psiquiatria, Hospital das Clnicas, Faculdade de Medicina, Universidade de So Paulo, Brazil, between 2007 and 2013. Recruitment took place during the initial intake interview at PRO-AMITI. During the intake process, patients were informed about the potential study and were invited to participate. They were clearly informed that treatment was not based on participation in the study. Patients who agreed to participate then completed the measures of interest and underwent a semi-structured clinical interview.

The inclusion criteria were as follows: i) a primary diagnosis of IED or NSSI; ii) formal education of at least 5 years; and (iii) age 18 years or older. IED or NSSI were diagnosed through semi-structured clinical interviews by registered and research-trained psychologists and psychiatrists. We used the DSM-IV Structured Clinical Interview (SCID)17 adapted for impulse-control disorders. Since NSSi is not an official diagnosis in the DSM-IV, the criteria were adapted from the Functional Assessment of Self-Mutilation (FASM).18 A similar approach has been used in previous studies on other impulse-control disorders without official DSM-IV criteria.19,20 We excluded individuals: i) who had both IED and NSSI; ii) presented with psychotic symptoms; iii) required emergency care; or iv) refused to participate in the study. Three individuals met the diagnostic criteria for both IED and NSSI. Due to the small sample size, we were unable to conduct robust statistical analyses in individuals with both disorders, and thus they were excluded from the final analyses.



We assessed the sample for age (in years), gender, ethnicity, marital status, educational level (in years of formal education), and professional status.

Clinical variables

The 75-item Buss-Durkee Hostility Inventory was used to evaluate aggressive/hostile behavior. The self-report questionnaire is divided in eight sub-factors: assault (10 items), irritability (11 items), indirect hostility (nine items), resentment (eight items), negativism (five items), guilt (nine items), suspicion (10 items), and verbal hostility (13 items). In addition to subscale scores, the factors can be summed to provide a total score.21 The Buss-Durkee Hostility Inventory has demonstrated good internal consistency (Cronbach's alpha between 0.72 and 0.79), test-retest reliability (stability coefficients between .64 and .82), and convergent validity (correlation coefficients between 0.40 and 0.70 for measurements of aggression/ hostility/anger).21

Impulsivity was investigated with the widely-used Barratt Impulsiveness Scale (BIS-11).22 This self-report questionnaire assesses three components of impulsivity: 1) motor; 2) attentional; and 3) lack of planning.22 The BIS-11 has high internal consistency (Cronbach's alpha between 0.79 and 0.82).22 The scale was translated to Brazilian Portuguese by Malloy-Diniz et al.23 and the translated version showed satisfactory psychometric properties, including high correlations with the English version.

Impairments in social adjustment was assessed using the Social Adjustment Scale (self-report), a 42-item inventory that evaluates participants' adjustment in seven areas: work, social and leisure activities, relationship with extended family, marital role, parental role, membership in the family unit, and economic situation.24 Each item is scored on a 5-point scale in which higher scores indicate greater impairment (1 = normal functioning; 5 = severe maladjustment).24 The Social Adjustment Scale was validated for Brazilian Portuguese by Gorenstein et al.25 The translated version could discriminate between psychiatric patients and individuals without mental disorders, and has been shown to be useful in outcome studies.

Depressive symptoms were assessed using the Beck Depression Inventory (BDI). This self-report instrument consists of 21 items evaluating depressive symptoms in the last 7 days and is one of the most widely used selfreport measures of depression.26 The total score ranges from 0 to 63, with higher scores indicating more severe depressive symptoms.26 It was adapted to Brazilian Portuguese and validated by Gorenstein & Andrade.27

Current prevalence of psychiatric comorbidities was assessed with the Mini International Neuropsychiatric Interview (MINI), a widely-used brief semi-structured interview that assess psychiatric disorders using DSM-IV criteria.28 The MINI has demonstrated reliable diagnoses compared to the Composite International Diagnostic Interview,28 and the Brazilian Portuguese of the MINI has also demonstrated satisfactory reliability.29,30

Statistical analysis

The two groups (IED and NSSI) were compared on demographic characteristics, clinical variables, and psychiatric comorbidities. Categorical variables were evaluated using chi-square tests. Fisher's exact test was used when cell counts were less than five. Student's t-tests were used for normally distributed continuous variables, and Mann-Whitney's U-tests were used for non-normally distributed continuous variables.


This study was approved by the ethics committee of Hospital das Clnicas, Universidade de So Paulo. Written informed consent was obtained from all participants. The study protocol followed Declaration of Helsinki guidelines for human experiments.


In terms of demographic characteristics, the IED group was older, more likely to be male, in a relationship, and employed (Table 1).

Regarding the clinical variables, the IED group scored higher on the Buss-Durkee Hostility Inventory than the NSSI group. Not surprisingly, individuals with IED reported higher levels of aggression directed towards others, such as verbal hostility and assault. Conversely, the NSSI group had more severe depressive symptoms, higher BIS total scores, as well as greater social adjustment difficulties. Regarding co-occurring psychiatric disorders, the IED group had higher rates of generalized anxiety disorder (GAD). On the other hand, the NSSI group had higher rates of major depressive disorder (MDD), agoraphobia, substance use disorder, and bulimia nervosa (Table 2).


The present study is, to our knowledge, the first to directly investigate the clinical differences between individuals with aggressive behavior primarily directed towards others (IED) and individuals with aggressive behavior primarily directed towards the self (NSSI). Several differences were found between the two subtypes of aggression, and some of our findings could have potential treatment implications. First, there were significant demographic differences between the groups. Second, the NSSI group had higher rates of psychiatric co-morbidities, including severe depressive symptoms and higher rates of MDD than the IED group. Third, the NSSI group reported poorer social adjustment than the IED group. Finally, the IED group had a higher prevalence of GAD than the NSSI group. These findings may provide insight for the development of tailored interventions for different subtypes of aggressive behavior (i.e., aggression directed towards others vs. aggression directed towards the self).

Differences in demographic characteristics

We found that individuals in the IED group were older and more likely to be male than those in the NSSI group. This age difference might be a result of discrepancies in the duration of the two disorders. The age of onset for NSSI is around 16 years. However, at age 20, half of the individuals tend to remit from self-injurious behaviors.31 The onset of IED is also during adolescence, with a mean age of onset between 14.0 and 16.2.6,32 In contrast to NSSI, however, IED persists longer.6,33 Kessler et al.6 observed a mean duration of approximately 12 years for IED. In addition, IED may be considered a more egosyntonic disorder,32 and thus individuals with IED may seek treatment later, which may account for the age difference between the groups in our study.

In terms of gender differences, our findings are consistent with previous studies in that males tend to present more aggression directed towards others than females.34 Male aggression towards others may be rooted in evolutionary traits related to fighting, survival and reproduction.34 In addition, testosterone has been found to decrease the amygdala-prefrontal coupling, which may affect emotional processing in males and tend to increase aggression directed towards others.35

Our findings also suggest that there is a need to reduce the time between IED onset and treatment seeking. Corroborating this, our results indicate that although IED onset is in adolescence,6,32 individuals seek treatment only in their early forties. Increased awareness that there is treatment for aggressive behavior may increase treatment-seeking behavior and reduce the negative consequences of aggression directed towards others.

Depressive symptoms and rates of major depressive disorder (MDD)

We found more severe depressive symptoms (measured by the BDI) and a higher prevalence of MDD in individuals with NSSI than IED. Although, individuals with IED have higher rates of MDD than the general population,6,9,36 MDD prevalence in the IED group was less than half that of the NSSI group. In addition, MDD was not only more frequent, but also more severe in individuals with NSSI. Depressed participants with NSSI had a mean BDI score of 29.9 (standard deviation [SD] = 11.8), while depressed participants with IED had an average score of 21.1 (SD = 10.2), p < 0.001. These results suggest that depression may be a particularly important co-morbidity in individuals with NSSI. This finding converges with the literature, which reports an association between NSSI and negative emotions, specifically that self-injurious behavior may briefly attenuate negative affect.9,10 Thus, it is plausible that individuals engage in NSSI to cope with their depression. As such, it may be important to manage depression symptoms to reduce self-injurious behavior. To this end, pharmacological and psychotherapeutic interventions focused on depressive manifestations might facilitate NSSI treatment. Moreover, the development of coping skills to deal with depressive symptoms in a more adaptable manner may be particularly useful.

Social adjustment

In the present study, the NSSI group reported poorer social adjustment than the IED group. There are several potential explanations for this finding. One possibility is that individuals with poorer social adjustment are more vulnerable to developing self-injurious behavior. Another possibility is that NSSI causes more negative consequences in global functioning and adjustment than IED. It is also possible that self-aggression further deteriorates the social adjustment of individuals with NSSI (i.e., a combination of the two factors). Corroborating these findings, previous studies have found that interpersonal difficulties may be a core component of social adjustment and functionality problems in NSSI.9,37 Therefore, therapeutic interventions focused on improving problem-solving strategies and interpersonal skills may be particularly helpful. Furthermore, peer-support and group psychotherapy may create a supportive environment in which individuals can share common concerns such as stigma and interpersonal difficulties.38

Prevalence of generalized anxiety disorder (GAD)

The IED group had a higher prevalence of GAD than the NSSI group. Previous studies have suggested that GAD is the most strongly associated psychiatric comorbidity with IED.6 One potential reason for the association between IED and GAD could be that the two disorders

share similar clinical and neurobiological aspects, including: a hyper-active amygdala,38,39 overstimulation of the adrenergic system, irritability, racing thoughts,2,3,9 and an association with the fight-or-flight response.39 In the present study, individuals with comorbid IED and GAD had higher mean and median hostility scores than individuals who had IED without comorbid GAD (Figure 1). Conversely, anxiety symptoms in NSSI appear to have a different clinical and neurobiological basis in that they appear to be more self-directed, internalizing and associated with self-criticism.36 According to Thompson & Zuroff,40 self-criticism is associated with low self-esteem, neuroticism and an avoidant conflict management style. Neuroimaging studies have also suggested that self-criticizing anxiety may be associated with increased activity in the dorsal anterior cingulate and the lateral prefrontal cortex.41

Figure 1 Level of hostile behavior (measured by Buss-Durkee Hostility Inventory) in participants with intermittent explosive disorder with and without co-occurring generalized anxiety disorder (GAD) (n=72 [sample sizes with GAD = 36; without GAD = 36]). There were no demographic differences between subjects with and without GAD.

Our study suggests that comorbid GAD appears to increase the severity of aggression directed toward others. Some treatments that may address IED and GAD simultaneously include selective serotonin reuptake inhibitors, exercise, communication skills to improve interpersonal relationships, and managing alcohol/substance use disorders.4,42,43


Our study should be interpreted in light of its limitations. First, it did not include healthy controls and, thus, we could not compare individuals with IED and NSSI to individuals without these clinical disorders. Nevertheless, our main goal was to investigate the clinical differences between aggression directed towards others and aggression directed towards the self. Despite the absence of healthy controls, our findings provide important insight into the different subtypes of aggression. Second, since our sample consisted of treatment-seeking participants, it may not be representative of the general population, and caution is needed when generalizing our results. That said, participants were recruited in a typical treatment setting and, thus, our findings could have high clinical utility. Third, we excluded individuals with both IED + NSSI due to the small sample size (n=3). Examining differences between individuals with IED, or NSSI and both IED + NSSI would be informative and a potential avenue for future research. Finally, it was beyond the scope of the paper to examine variables that mediate/moderate the effects between our variables of interest. However, such research would be highly informative and provide more insight into the relationship between pathological aggression (others, self) and its clinical characteristics.


The present study found several clinical differences between individuals with aggression predominantly directed towards others (IED) and individuals with aggression primarily directed towards the self (NSSI). Our results may provide important insight for the development of tailored interventions for specific subtypes of aggression. For example, individuals with NSSI may particularly benefit from a better management of depressive symptoms and difficulties in social adjustment. On the other hand, treatments for individuals with IED may wish to target comorbid GAD in conjunction with the aggressive behavior. Indeed, such tailored interventions may help increase treatment efficacy for different subtypes of aggression.


EFC is a member of the Scientific Advisory Board of Azevan Pharmaceuticals, Inc. HT receives compensation from the Caixa Econmica Federal to develop responsible gambling interventions. The other authors report no conflicts of interest.


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